She played a Spanish-speaking student in Kindergarten Cop at age 5. She then didn't act for six more years as her parents wanted her to experience a normal childhood and make the choice about acting when she was was old to decide.
Annable played Melanie Garcia on the comedy Breaking In as a series regular in its first season, appearing as a guest star thereafter. She joined the TV series House as Dr. Jessica Adams, and remained on the show until the finale in May 2012.
In March 2014, Annable was cast in the ABC shorted lived series The Astronaut Wives Club
In 2017, she joined the main cast of Supergirl for the third season as Samantha Arias, a single mother who discovers that she shares origins with Supergirl and Superman, as well as Reign, the Kryptonian Worldkiller she was engineered to be. She later reprised that role in the 100th episode of the series. Most recently she starred in the second season of Tell Me a Story originally an All CBS Access Series which sold its television broadcast rights to the CW where she played Maddie Pruitt.
In 2020, it was announced that Odette had joined the cast of The CW's Walker in a guest starring role. She played Geri Broussard, a bartender and close friend of the Walker family. Mid-way through filming the first season, Odette was upped to a series regular role for Season 2.
Odette married her Brothers & Sisters co-star Dave Annable in October 2010. She gave birth to a daughter in September 2015. In October 2019, the couple announced their separation, but announced their reconciliation in August of 2020.
- According to Anna Fricke Odette knows everything about the Season 1 mystery as her character is connected to it.